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A recent study found that an anti-inflammatory drug increased the lifespan of mice by up to 20 percent. The research suggests that if the same drug were used in humans, it could help extend lifespan and reduce age-related diseases.
In the study, scientists blocked a molecule called Interleukin-11 (IL-11), which causes inflammation. IL-11 promotes inflammation in the body and becomes more active with age.
Researchers tested the drug by injecting it into 37 mice aged 75 weeks — roughly equivalent to 55 years in human age. The drug was administered every three weeks. Another group of 38 mice received a different drug that did not target IL-11.
The results showed that the mice treated with the IL-11 blocking drug lived up to 20 percent longer. They also had a lower risk of developing cancer — only 16 percent of the treated mice developed tumors, compared to 60 percent in the other group.
Additionally, the drug reduced cholesterol levels, frailty, and body weight in the mice. Their muscle strength and metabolism also improved.
It’s still unclear whether the drug will have the same effects in humans. Some human trials are currently underway, but they are focused on specific inflammatory conditions such as pulmonary fibrosis.
Dr. Stuart Cook, the lead scientist of the study, believes that reducing inflammation could help minimize age-related health issues. However, more research is needed to understand its effects in humans.
This study may point toward a new direction, but further investigation is necessary to determine its impact on people.
Journal Reference: Nature